Try launching Doki Doki Literature Club Plus in windowed mode to help your computer process everything. Running a game in fullscreen consumes a lot of processing resources, which can cause the game to become unresponsive at times. Launch Doki Doki Literature Club Plus in Windowed Mode
In the Local Files section, click the Verify integrity of game files button.On the left side, find Doki Doki Literature Club Plus and right-click then select Properties.
